Volume 4, Issue 2 (December 2018)                   Elderly Health Journal 2018, 4(2): 35-36 | Back to browse issues page

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Dehghani A, Safari F. Klotho as a Novel Cardioprotective Protein in Aged Heart. Elderly Health Journal. 2018; 4 (2) :35-36
URL: http://ehj.ssu.ac.ir/article-1-127-en.html
Department of Physiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract:   (69 Views)
 In recent years, researchers have been looking for genes whose products can directly affect the aging process. Among these, the anti-aging protein klotho has attracted much attention. This single transmembrane protein is expressed in the renal tissues, parathyroid gland and choroid network of the brain and acts as a co-receptor for Fibroblast Growth Factor FGF. In this way, it contributes to calcium and phosphate homeostasis, which is in fact the classical function of this protein. The second extracellular protein of this protein can be released from cell surface by ectodomain shedding and get secreted into the blood, which, in turn, as an “endocrine factor”, affects the body in many ways.
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Type of Study: Research | Subject: General
Received: 2018/10/23 | Accepted: 2018/12/1 | Published: 2018/12/29

1. Kuro-o M. Klotho and aging. Biochim Biophys Acta. 2009; 1790 (10): 1049-58.
2. Ai F, Chen M, Li W, Yang Y, Xu G, Gui F, et al. Protective role of Klotho on cardiomyocytes upon hypoxia/reoxygenation via downregulation of Akt and FOXO1 phosphorylation. Molecular Medicine Reports. 2015; 11 (3): 2013-9.
3. Corsetti G, Pasini E, Scarabelli TM, Romano C, Agrawal PR, Chen-Scarabelli C, et al. Decreased expression of Klotho in cardiac atria biopsy samples from patients at higher risk of atherosclerotic cardiovascular disease. Journal of Geriatric Cardiology. 2016; 13 (8): 701-11.
4. Keles N, Caliskan M, Dogan B, Keles NN, Kalcik M, Aksu F, et al. Low serum level of klotho is an early predictor of atherosclerosis. The Tohoku Journal of Experimental Medicine. 2015; 237(1): 17-23.
5. Song S, Si LY. Klotho ameliorated isoproterenol-induced pathological changes in cardiomyocytes via the regulation of oxidative stress. Life Sciences. 2015; 135: 118-23.
6. Song S, Gao P, Xiao H, Xu Y, Si LY. Klotho suppresses cardiomyocyte apoptosis in mice with stress-induced cardiac injury via downregulation of endoplasmic reticulum stress. PLoS One. 2013; 8(12): 1-14.
7. Xiao NM, Zhang YM, Zheng Q, Gu J. Klotho is a serum factor related to human aging. Chinese Medical Journal (Engl). 2004; 117(5): 742-7.
8. Kitagawa M, Sugiyama H, Morinaga H, Inoue T, Takiue K, Ogawa A, et al. A decreased level of serum soluble Klotho is an independent biomarker associated with arterial stiffness in patients with chronic kidney disease. PLoS One. 2013; 8(2): 1-10.
9. Semba RD, Cappola AR, Sun K, Bandinelli S, Dalal M, Crasto C, et al. Plasma klotho and mortality risk in older community-dwelling adults. The Journal Gerontology. Series A, Biological Sciences and Medical Sciences. 2011; 66(7): 794-800.

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