Volume 7, Issue 2 (December 2021)                   Elderly Health Journal 2021, 7(2): 99-106 | Back to browse issues page


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Saberianpour S. Vascular Aging and Diseases: Molecular Mechanisms and Influences. Elderly Health Journal. 2021; 7 (2) :99-106
URL: http://ehj.ssu.ac.ir/article-1-204-en.html
Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran , saberianpoursh@mums.ac.ir
Abstract:   (275 Views)
Vascular aging plays an important role in the mortality of the elderly, but vascular aging can be dependent on other factors such as diseases. Various diseases such as Alzheimer, diabetes, thalassemia, and other diseases affect the mechanisms of vascular aging. It will harm the recovery process of these patients. There are methods for measuring vascular aging such as instrumental measurements and molecular methods. The best way to measure vascular aging is a combination of methods to determine the mechanism and cause of vascular aging. In this review article, we first summarize the various mechanisms of vascular aging and then discuss the effect of different disease on vascular aging.
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Type of Study: Applicable | Subject: Special
Received: 2020/09/19 | Accepted: 2021/11/24 | Published: 2021/12/19

References
1. Rizzoni D, Rizzoni M, Nardin M, Chiarini G, Agabiti-Rosei C, Aggiusti C, et al. Vascular aging and disease of the small vessels. High Blood Pressure & Cardiovascular Prevention 2019: 1-7.
2. Ungvari Z, Tarantini S, Donato AJ, GalvanV, Csiszar A. Mechanisms of vascular aging. Circulation Research. 2018; 123: 849-67.
3. Mistriotis P, Andreadis ST. Vascular aging: molecular mechanisms and potential treatments for vascular rejuvenation. Ageing Research Reviews. 2017; 37: 94-116.
4. Buford L, Kaiser R, Petronic-Rosic V. Vascular diseases in the mature patient. Clinics in Dermatology. 2018; 36(2): 239-48.
5. Guzik TJ, Touyz RM. Oxidative stress, inflammation, and vascular aging in hypertension. Hypertension. 2017; 70: 660-7.
6. Ghebre YT, Yakubov E, Wong WT, Krishnamurthy P, Sayed N, Sikora AG, et al. Vascular aging: implications for cardiovascular disease and therapy. Translational Medicine (Sunnyvale, Calif). 2016; 6(4): 1-20.
7. Alfonso MR, Armentano RL, Cymberknop LJ, Ghigo AR, Pessana FM, Legnani WE. A novel interpretation for arterial pulse pressure amplification in health and disease. Journal of Healthcare Engineering. 2018; 2018: 1-10.
8. Davies, Bailey MA, Griffin KJ, Scott DJ. Pulse wave velocity and the non-invasive methods used to assess it: Complior, SphygmoCor, Arteriograph and Vicorder. Vascular. 2012: 20(6): 342-9.
9. Wernick MB, Höpfner RM, Francey T, Howard J. Comparison of arterial blood pressure measurements and hypertension scores obtained by use of three indirect measurement devices in hospitalized dogs. Journal of the American Veterinary Medical Association. 2012; 240(8): 962-8.
10. Asmar R, Benetos A, Topouchian J, Laurent P, Pannier B, Brisac AM, et al. Assessment of arterial distensibility by automatic pulse wave velocity measurement: validation and clinical application studies. Hypertension. 1995; 26(3): 485-90.
11. Nowak KL, Rossman MJ, Chonchol M, Seals DR. Strategies for achieving healthy vascular aging. Hypertension. 2018; 71(3): 389-402.
12. Laurent S. How to assess vascular aging. Journal of Hypertension Research. 2018; 4: 39-52.
13. Bruno RM, Duranti E, Ippolito C, Segnani C, Bernardini N, Candio GD, et al. Different impact of essential hypertension on structural and functional age-related vascular changes. Hypertension. 2016; 69(1): 1-9.
14. Moriya J, Minamino T. Angiogenesis, cancer, and vascular aging. Frontiers in Cardiovascular Medicine. 2017; 4: 1-7.
15. Gordon LB, Brown WT, Collins FS. Hutchinson-gilford progeria syndrome. In: Adam MP, Ardinger HH, Pagon RA, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 2019.
16. Hamczyk MR, del Campo L, Andrés V. Aging in the cardiovascular system: lessons from hutchinson-gilford progeria syndrome. Annual Review of Physiology. 2018; 80: 27-48.
17. Mahmud A, Feely J. Effects of passive smoking on blood pressure and aortic pressure waveform in healthy young adults–influence of gender. British Journal of Clinical Pharmacology. 2004; 57(1): 37-43.
18. Safar ME, Boudier HS. Vascular development, pulse pressure, and the mechanisms of hypertension. Hypertension. 2005; 46(1): 205-9.
19. Eikendal AL, den Ruijter HM, Haaring C, Saam T, Geest R,Westenberg JM, et al. Sex, body mass index, and blood pressure are related to aortic characteristics in healthy, young adults using magnetic resonance vessel wall imaging: the AMBITYON study. Magnetic Resonance Materials in Physics, Biology and Medicine. 2018; 31(1): 173-182.
20. Furst B. Arterial Pulse. In: The Heart and Circulation. Springer: Cham; 2020. p.263-86.
21. Kotsis V, Stabouli S, Karafillis I, Peter N. Early vascular aging and the role of central blood pressure. Journal of Hypertension. 2011; 29(10): 1847-53
22. Zekavat SM, Aragam K, Emdin C, Khera A, Klarin D, Zhao H,et al. Genetic association of finger photoplethysmography-derived arterial stiffness index with blood pressure and coronary artery disease. Arteriosclerosis, Thrombosis, and Vascular Biology. 2019; 39(6): 1253-61.
23. Golshiri K, Ataabadi EA , Rubio-Beltran E, Dutheil S, Yao W, Snyder GL, et al. Selective Phosphodiesterase 1 Inhibition Ameliorates Vascular Function, Reduces Inflammatory Response, and Lowers Blood Pressure in Aging Animals. Journal of Pharmacology and Experimental Therapeutics. 2021; 378(2): 173-83.
24. Zieman SJ, Melenovsky V, Kass DA. Mechanisms, pathophysiology, and therapy of arterial stiffness. Arteriosclerosis, Thrombosis, and Vascular Biology. 2005; 25(5): 932-43.
25. Selzer F, Sutton-Tyrrell K, Fitzgerald SG, Pratt J, Tracy R, Kuller LH, et al. Comparison of risk factors for vascular disease in the carotid artery and aorta in women with systemic lupus erythematosus. Arthritis & Rheumatism. 2004; 50(1): 151-9.
26. Willmot M, Leonardi-Be J, Bath PM. High blood pressure in acute stroke and subsequent outcome: a systematic review. Hypertension. 2004; 43(1): 18-24.
27. Calder PC, Bosco N, Bourdet-Sicard R, Capuron L, Delzenne N, Franceschi C, et al. Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition. Ageing Research Reviews. 2017; 40: 95-119.
28. Luca M, Luca A, Calandra C. The role of oxidative damage in the pathogenesis and progression of Alzheimer’s disease and vascular dementia. Oxidative Medicine and Cellular Longevity. 2015; 2015(6): 1-8.
29. Csiszar A, Sosnowska D, Wang M, Lakatta EG, Sonntag WE, Ungvari Z. Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences. 2012; 67(8): 811-820.
30. Ungvari Z, Csiszar A, Kaley G. Vascular inflammation in aging. Herz. 2004; 29(8): 733-40.
31. Mattson MP. Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associated vascular and neurodegenerative disorders. Experimental Gerontology. 2009; 44(10): 625-33.
32. Strand BH, Grøholt E-K, Steingrímsdóttir OA, Blakely T, Graff-Iversen s, Næss Ø, et al. Educational inequalities in mortality over four decades in Norway: prospective study of middle aged men and women followed for cause specific mortality, 1960-2000. British Medical Journal. 2010; 340: 1-10.
33. Sader MA, McCredie RJ, Griffiths KA, Wishart SM, Handelsman DJ, Celermajer DS. Oestradiol improves arterial endothelial function in healthy men receiving testosterone. Clinical Endocrinology. 2001; 54(2): 175-81.
34. Moreau KL, Hildreth KL, Klawitter J, Blatchford P, Kohrt WM. Decline in endothelial function across the menopause transition in healthy women is related to decreased estradiol and increased oxidative stress. GeroScience. 2020; 42(6): 1699-714
35. Aversa A, Bruzziches R, Francomano D, Natali M, Gareri P, Spera G. Endothelial dysfunction and erectile dysfunction in the aging man. International Journal of Urology. 2009; 17(1): 38-47.
36. Buijs J, Musters M, Verrips T, Post JA, Braam B, Riel NV. Mathematical modeling of vascular endothelial layer maintenance: the role of endothelial cell division, progenitor cell homing, and telomere shortening. American Journal of Physiology-Heart and Circulatory Physiology. 2004; 287(6): 2651-8.
37. Levenson J, Pessana F, Gariepy J, Armentano R, Simon A. Gender differences in wall shear–mediated brachial artery vasoconstriction and vasodilation. Journal of the American College of Cardiology. 2001; 38(6): 1668-74.
38. Sakabe K, Fukuda N, Fukuda T, Wakayama K, Nada T, Morishita S, et al. Gender differences in short-term effects of atorvastatin on lipid profile, fibrinolytic parameters, and endothelial function. Nutrition, Metabolism and Cardiovascular Diseases. 2008; 18(3): 182-8.
39. Moreau KL. Modulatory influence of sex hormones on vascular aging. American Journal of Physiology-Heart and Circulatory Physiology. 2019; 316(3): 522-6.
40. Moreau KL. Intersection between gonadal function and vascular aging in women. Journal of Applied Physiology. 2018; 125(6): 1881-7.
41. Moreau KL, Hildreth KL. Vascular aging across the menopause transition in healthy women. Advances in Vascular Medicine. 2014; 2014: 1-25.
42. Somani YB, Pawelczyk JA, De Souza MJ, Kris-Etherton P, Proctor D. Aging women and their endothelium: Probing the relative role of estrogen on vasodilator function. American Journal of Physiology-Heart and Circulatory Physiology. 2019; 317(2): 395-404.
43. Nyberg M, Seidelin K, Andersen TR, Overby NN, Hellsten Y, Bangsbo J. Biomarkers of vascular function in premenopausal and recent postmenopausal women of similar age: effect of exercise training. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2014; 306(7): 510-7.
44. Yao F, Zhang Y, Huang Y, Ma H, Dong Y, Deng L, et al. Subclinical endothelial dysfunction and low-grade inflammation play roles in the development of erectile dysfunction in young men with low risk of coronary heart disease. Heart. 2011; 97(3): 653-659.
45. Wang C, Jackson G, Jones TH, Matsumoto A, Nehra A, Perelman M, et al. Low testosterone associated with obesity and the metabolic syndrome contributes to sexual dysfunction and cardiovascular disease risk in men with type 2 diabetes. Diabetes Care. 2011; 34(7): 1669-75.
46. Bar DZ, Arlt MF, Brazier JF, Norris W, Campbell SE, Chines P, et al. A novel somatic mutation achieves partial rescue in a child with hutchinson-gilford progeria syndrome. Journal of Medical Genetics. 2017; 54(3): 212-6.
47. Brassard JA, Fekete N, Garnier A, Hoesli CA. Hutchinson–gilford progeria syndrome as a model for vascular aging. Biogerontology. 2016; 17: 129-45.
48. Petrie JR and Salt IP. Diabetes and vascular disease. In: Touyz RM, Delles CH. Textbook of Vascular Medicine. Springer; 2019. p.429-37.
49. Kumar A, Patel DR, Wolski KE, Lincoff AM, Kashyap SR, Ruotolo G, et al. Baseline fasting plasma insulin levels predict risk for major adverse cardiovascular events among patients with diabetes and high-risk vascular disease: Insights from the ACCELERATE trial. Diabetes and Vascular Disease Research. 2019; 16(2): 171-7.
50. Groeneveld ON, van den Berg E, Johansen OE, Schnaidt S, Hermansson K, Zinman B, et al. Oxidative stress and endothelial dysfunction are associated with reduced cognition in type 2 diabetes. Diabetes and Vascular Disease Research. 2019; 16(6): 577-81.
51. Maamoun H, Abdelsalam SS, Zeidan A, Korashy HM, Agouni A. Endoplasmic reticulum stress: A critical molecular driver of endothelial dysfunction and cardiovascular disturbances associated with diabetes. International Journal of Molecular Sciences. 2019; 20(7): 1-21.
52. Maruhashi T, Higashi Y. Pathophysiological association between diabetes mellitus and endothelial dysfunction. Antioxidants. 2021; 10(8): 1306.
53. Toya T, Ahmad A, Attia Z, Cohen-Shelly M, OzcanI, Noseworthy PA, et al. Vascular aging detected by peripheral endothelial dysfunction is associated with ECG-derived physiological aging. Journal of the American Heart Association. 2021; 10(3): 018656.
54. Halim M, Halim A. The effects of inflammation, aging and oxidative stress on the pathogenesis of diabetes mellitus (type 2 diabetes). Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2019; 13(2): 1165-72.
55. Chan HC, Chan HC, Liang CJ, Lee HC, Su H, Lee AS, et al. Role of low-density lipoprotein in early vascular aging associated with systemic lupus erythematosus. Circulation. 2019; 140(1).
56. Perna M, Roman MJ, Alpert DR, Crow M, Lockshin M, Sammaritano LR, et al. Relationship of asymmetric dimethylarginine and homocysteine to vascular aging in systemic lupus erythematosus patients. Arthritis & Rheumatism. 2010; 62(6): 1718-22.
57. Stortz M, Triantafyllias K, Schwarting A, Menke J. Vascular stiffness: influencing factors on carotid-femoral pulse wave velocity in systemic lupus erythematosus. Clinical and Experimental Rheumatology. 2020; 38(1): 74-81.
58. Dai L, Schurgers LJ, Shiels PG, Stenvinkel P. Early vascular ageing in chronic kidney disease: impact of inflammation, vitamin K, senescence and genomic damage. Nephrology Dialysis Transplantation. 2020; 35(2): 31-7.
59. Hobson S, Arefin S, Kublickiene K, Shiels P, Stenvinkel P. Senescent cells in early vascular ageing and bone disease of chronic kidney disease—a novel target for treatment. Toxins. 2019; 11(2): 1-13.
60. Singh MM, Kumar R, Tewari S, Agarwal S. No association of genetic markers with carotid intimal medial thickness in β-thalassemia major patients. Journal of Pediatric Genetics. 2018; 7(1): 19-22.
61. Adly AAM, ElSherif NHK, Ismail EAR, Ibrahim YA, Niazi G, Elmetwally SH. Ischemia-modified albumin as a marker of vascular dysfunction and subclinical atherosclerosis in β-thalassemia major. Redox Report. 2017; 22(6): 430-8.
62. Sweeney MD, Montagne A, Sagare AP, Nation D, Schneider LS, Chui HC, et al. Vascular dysfunction—the disregarded partner of Alzheimer's disease. Alzheimer's & Dementia. 2019; 15(1): 158-67.
63. Liesz A. The vascular side of Alzheimer's disease. Science. 2019; 365(6450): 223-4.
64. Cortes-Canteli M, Iadecola C. Alzheimer’s Disease and vascular aging: JACC focus seminar. Journal of the American College of Cardiology. 2020; 75(8): 942-51.
65. Venturelli M. The Role of Nitric Oxide on vascular dysfunction during aging and Alzheimer’s disease. In: Morbidelli L, Bonavida B, editor. Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders. Elsevire; 2019. p. 221-8.
66. Saeed S, Waje-Andreassen U, Fromm A, Øygarden H, Kokorina M, Naess H, et al. Early vascular aging in young and middle-aged ischemic stroke patients: the Norwegian Stroke in the Young Study. PloS One. 2014; 9(11): 1-6.
67. Hachinski V, Iadecola C, Petersen RC, Breteler M, Nyenhuis D, Black S, et al. National Institute of Neurological Disorders and Stroke–Canadian stroke network vascular cognitive impairment harmonization standards. Stroke. 2006; 37(9): 2220-41.
68. Barton M. Obesity and aging: determinants of endothelial cell dysfunction and atherosclerosis. Pflügers Archiv-European Journal of Physiology. 2010; 460(5): 825-37.
69. Bailey-Downs LC, Sosnowska D, Toth P, Mitschelen M, Gautam T, Henthorn J, et al. Growth hormone and IGF-1 Deficiency exacerbate high-fat diet–induced endothelial impairment in obese lewis dwarf rats: implications for vascular aging. The Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences. 2012; 67(6): 553-64.
70. Bailey-Downs LC, Tucsek Z, Toth P, Sosnowska D, Gautam T, Sonntag WE, et al. Aging exacerbates obesity-induced oxidative stress and inflammation in perivascular adipose tissue in mice: a paracrine mechanism contributing to vascular redox dysregulation and inflammation. The Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences. 2013; 68(7): 780-92.
71. Ungvari Z, Parrado-Fernandez C, Csiszar A, Cabo R. Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging. Circulation Research. 2008; 102(5): 519-28.
72. Georgiopoulos GA, Lambrinoudaki I, Athanasouli F, Armeni E, Rizos D, Kazani M, et al. Free androgen index as a predictor of blood pressure progression and accelerated vascular aging in menopause. Atherosclerosis. 2016; 247: 177-183.

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