Volume 7, Issue 1 (June 2021)                   Elderly Health Journal 2021, 7(1): 39-44 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mehboudi M, Asgharpour H, Hosseini S A, Rezaeeshirazi R. Effect of a Six Week-Swimming Interval Training with Resveratrol Consumption on Apoptotic Markers in the Liver Tissue of Aged Rat. Elderly Health Journal. 2021; 7 (1) :39-44
URL: http://ehj.ssu.ac.ir/article-1-217-en.html
Department of Physical Education and Sport Sciences, Aliabad Katoul Branch, Islamic Azad University, Aliabad Katoul, Iran , habibasgharpour@gmail.com
Abstract:   (422 Views)
Introduction: Aging involves a decrease in  physiological function, physical activity and nutrition that modulate body functions. The aim of this study was to evaluate the effect of a six week-swimming interval training with resveratrol consumption on apoptotic markers in the liver tissue of aged rat.
Methods: In this experimental study, thirty-two 20-month aged rats weighing 350-370 g were divided into four groups of 8 rats including 1) sham, 2) training, 3) resveratrol and 4) training + resveratrol. For six weeks, groups 3 and 4 received 100 mg/kg of resveratrol supplementation dissolved in 1% methylcellulose daily by gavage, and groups 2 and 4 performed swimming training three times a week. One-way analysis of variance with Tukey's post- hoc test was used to analyze the data (p < 0.05).
Results: Bcl2 Gene expression levels in the resveratrol and the exercise + resveratrol groups were significantly higher than the sham and exercise groups (p < 0.05).  Bax levels in the exercise + resveratrol group were lower than the resveratrol group, and the levels in the resveratrol group were higher than the sham group(p <0.05).also Bax/Bcl2 levels in the exercise + resveratrol group were significantly lower than the exercise group(p < 0.05).
Conclusion: It seems that swimming interval training with resveratrol consumption has beneficial effects on anti-apoptotic markers, however, the effect of swimming interval training on liver apoptosis in the aging is still unknown and more studies are needed in this field.
Full-Text [PDF 897 kb]   (197 Downloads) |   |   Full-Text (HTML)  (135 Views)  
Type of Study: Research | Subject: General
Received: 2021/01/10 | Accepted: 2021/05/25 | Published: 2021/06/27

1. Farzanegi P, Dana A, Ebrahimpoor Z, Asadi M, Azarbayjani MA. Mechanisms of beneficial effects of exercise training on non-alcoholic fatty liver disease (NAFLD): Roles of oxidative stress and inflammation. European Journal of Sport Science. 2019; 19(7): 994–1003.
2. Moradi M, Shakerian S, Nikbakht M. The effect of eight weeks high intensity interval training and crocin consumption on oxidative stress of liver tissue in male rats subjected to chronic doxorubicin injection. Journal of Kashan University of Medical Sciences. 2019; 23(5): 485–94. [Persian]
3. Afroozi-Gerow E, Afzalpour ME, TaheriChadorneshin H, Abtahi-Eivary SH. Effect of high intensity interval training on 8-oxoguanine DNA glycosylase and 8-hydroxy-2’-deoxyguanosine contents in the brain and liver of rats. Journal of Applied Pharmaceutical Science. 2016; 6(10): 170–3.
4. Shirpour S, Azarbayjani MA, Peeri M, Farzanegi P. Effect of high intensity interval training with curcumin on gene expression of Bax, Bcl-2, and Caspase-3 in aged female rat hepatocytes. Report of Health Care Jornal. 2017; 3(3):8–14.
5. Seif el-Din SH, El-Lakkany NM, Salem MB, Hammam OA, Saleh S, Botros SS. Resveratrol mitigates hepatic injury in rats by regulating oxidative stress, nuclear factor-kappa B, and apoptosis. Journal of Advanced Pharmaceutical Technology & Research. 2016; 7(3): 99-104.
6. Ghowsi M, Khazali H, Sisakhtnezhad S. The effect of resveratrol on oxidative stress in the liver and serum of a rat model of polycystic ovary syndrome: An experimental study. International Journal of Reproductive Biomedicine. 2018; 16(3): 149-58.
7. Peiyuan H, Zhiping H, Chengjun S, Chunqing W, Bingqing L, Imam MU. Resveratrol ameliorates experimental alcoholic liver disease by modulating oxidative stress. Evidence-Based Complementary and Alternative Medicine. 2017; 2017: 1-10.
8. Shadfar S, Couch ME, McKinney KA, Weinstein LJ, Yin X, Rodríguez JE, et al. Oral resveratrol therapy inhibits cancer-induced skeletal muscle and cardiac atrophy in vivo. Nutrition and Cancer. 2011; 63(5): 749–62.
9. Terada S, Yokozeki T, Kawanaka K, Ogawa K, Higuchi M, Ezaki O, et al. Effects of high-intensity swimming training on GLUT-4 and glucose transport activity in rat skeletal muscle. Journal of Applied Physiology. 2001; 90(6): 2019–24.
10. Ammar A, Trabelsi K, Boukhris O, Glenn JM, Bott N, Masmoudi L, et al. Effects of aerobic-, anaerobic-and combined-based exercises on plasma oxidative stress biomarkers in healthy untrained young adults. International Journal of Environmental Research and Public Health. 2020; 17(7): 1-12.
11. Soori R, Ghram A, Zare M, Choobineh S, Costa PB, Voltarelli FA, et al. Effects of high intensity interval training and aging on cardiac muscle apoptosis markers in C57BL/6 Mice. Sport Sciences for Health. 2020; 17(12): 1–7.
12. Pourrazi H, Asgharpour-Arshad M, Gholami F, Abbasi S. Effect of high-intensity interval training on apoptotic gene expression in rat myocardial tissue. Gene Cell and Tissue. 2020; 7(2): 1-6.
13. Abdelbasset WK, Tantawy SA, Kamel DM, Alqahtani BA, Elnegamy TE, Soliman GS, et al. Effects of high-intensity interval and moderate-intensity continuous aerobic exercise on diabetic obese patients with nonalcoholic fatty liver disease: a comparative randomized controlled trial. Medicine (Baltimore). 2020; 99(10): 1-6.
14. Shaito A, Posadino AM, Younes N, Hasan H, Halabi S, Alhababi D, et al. Potential adverse effects of resveratrol: a literature review. International Journal of Molecular Sciences. 2020; 21(6): 1-26.
15. Greifová H, Jambor T, Tokárová K, Speváková I, Knížatová N, Lukáč N. Resveratrol attenuates hydrogen peroxide-induced oxidative stress in TM3 Leydig cells in vitro. Journal of Environmental Science and Health. 2020; 55(5):585–95.
16. Keshtkar S, Kaviani M, Jabbarpour Z, Al-Abdullah IH, Aghdaei MH,. Nikeghbalian S, et al. Significant reduction of apoptosis induced via hypoxia and oxidative stress in isolated human islet by resveratrol. Nutrition, Metabolism, and Cardiovascular Diseases. 2020; 30(7): 1216-26.
17. Hosoda R, Hamada H, Uesugi D, Iwahara N, Nojima I, Horio Y, et al. Different antioxidative and antiapoptotic effects of piceatannol and resveratrol. Journal of Pharmacology and Experimental Therapeutics. 2020; 376(1): 1-42.
18. Mehri A, Hosseinpour Delaware S, Azizi M, Azarbaijani MA, Farzangi P. The effect of aerobic training and resveratrol on some regulatory and executive factors of cardiomyocytes apoptosis in STZ-diabetic male rats. Medical Science Journal of Islamic Azad Univesity-Tehran Medical Branch. 2020; 30(1): 59–66. [Persian] Hajighasem A, Farzanegi P, Mazaheri Z, Naghizadeh M, Salehi G. Effects of resveratrol, exercises and their combination on farnesoid x receptor, liver x receptor and sirtuin 1 gene expression and apoptosis in the liver of elderly rats with nonalcoholic fatty liver. PeerJ. 2018; 6(9): 1-15.

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2022 CC BY-NC 4.0 | Elderly Health Journal

Designed & Developed by : Yektaweb