Volume 7, Issue 1 (June 2021)
Elderly Health Journal 2021, 7(1): 39-44 |
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Mehboudi M, Asgharpour H, Hosseini S A, Rezaeeshirazi R. Effect of a Six Week-Swimming Interval Training with Resveratrol Consumption on Apoptotic Markers in the Liver Tissue of Aged Rat. Elderly Health Journal 2021; 7 (1) :39-44
URL: http://ehj.ssu.ac.ir/article-1-217-en.html
URL: http://ehj.ssu.ac.ir/article-1-217-en.html
Department of Physical Education and Sport Sciences, Aliabad Katoul Branch, Islamic Azad University, Aliabad Katoul, Iran , habibasgharpour@gmail.com
Abstract: (1640 Views)
Introduction: Aging involves a decrease in physiological function, physical activity and nutrition that modulate body functions. The aim of this study was to evaluate the effect of a six week-swimming interval training with resveratrol consumption on apoptotic markers in the liver tissue of aged rat.
Methods: In this experimental study, thirty-two 20-month aged rats weighing 350-370 g were divided into four groups of 8 rats including 1) sham, 2) training, 3) resveratrol and 4) training + resveratrol. For six weeks, groups 3 and 4 received 100 mg/kg of resveratrol supplementation dissolved in 1% methylcellulose daily by gavage, and groups 2 and 4 performed swimming training three times a week. One-way analysis of variance with Tukey's post- hoc test was used to analyze the data (p < 0.05).
Results: Bcl2 Gene expression levels in the resveratrol and the exercise + resveratrol groups were significantly higher than the sham and exercise groups (p < 0.05). Bax levels in the exercise + resveratrol group were lower than the resveratrol group, and the levels in the resveratrol group were higher than the sham group(p <0.05).also Bax/Bcl2 levels in the exercise + resveratrol group were significantly lower than the exercise group(p < 0.05).
Conclusion: It seems that swimming interval training with resveratrol consumption has beneficial effects on anti-apoptotic markers, however, the effect of swimming interval training on liver apoptosis in the aging is still unknown and more studies are needed in this field.
Methods: In this experimental study, thirty-two 20-month aged rats weighing 350-370 g were divided into four groups of 8 rats including 1) sham, 2) training, 3) resveratrol and 4) training + resveratrol. For six weeks, groups 3 and 4 received 100 mg/kg of resveratrol supplementation dissolved in 1% methylcellulose daily by gavage, and groups 2 and 4 performed swimming training three times a week. One-way analysis of variance with Tukey's post- hoc test was used to analyze the data (p < 0.05).
Results: Bcl2 Gene expression levels in the resveratrol and the exercise + resveratrol groups were significantly higher than the sham and exercise groups (p < 0.05). Bax levels in the exercise + resveratrol group were lower than the resveratrol group, and the levels in the resveratrol group were higher than the sham group(p <0.05).also Bax/Bcl2 levels in the exercise + resveratrol group were significantly lower than the exercise group(p < 0.05).
Conclusion: It seems that swimming interval training with resveratrol consumption has beneficial effects on anti-apoptotic markers, however, the effect of swimming interval training on liver apoptosis in the aging is still unknown and more studies are needed in this field.
Type of Study: Research |
Subject:
General
Received: 2021/01/10 | Accepted: 2021/05/25 | Published: 2021/06/27
Received: 2021/01/10 | Accepted: 2021/05/25 | Published: 2021/06/27
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