en عمومى General پژوهشي Research  In recent years, researchers have been looking for genes whose products can directly affect the aging process. Among these, the anti-aging protein klotho has attracted much attention. This single transmembrane protein is expressed in the renal tissues, parathyroid gland and choroid network of the brain and acts as a co-receptor for Fibroblast Growth Factor FGF. In this way, it contributes to calcium and phosphate homeostasis, which is in fact the classical function of this protein. The second extracellular protein of this protein can be released from cell surface by ectodomain shedding and get secreted into the blood, which, in turn, as an “endocrine factor”, affects the body in many ways. Klotho, cardioprotective, protein 35 36 http://ehj.ssu.ac.ir/browse.php?a_code=A-10-142-1&slc_lang=en&sid=1 Ali Dehghani No Department of Aging Health, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Fatemeh Safari 0000-0003-3943-8803 Yes Department of Physiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran